Nucleotide Nanofiltration Membrane Purification and Concentration Integrated System

      Nucleotides are the basic building blocks of RNA and DNA, possessing significant biological functions. They participate in almost all biochemical reaction processes within living organisms and have broad application prospects and development potential in fields such as medicine and infant food.

      Traditional methods for separating nucleotides, such as chromatography and ion exchange resins, have limitations including inability for industrial-scale production and high costs. Related technologies have long been monopolized by foreign countries. However, with their applications in pharmaceuticals, health products, food additives, and genetic engineering, this monopoly has gradually been broken. The rapid development of biotechnology has placed higher demands on corresponding product separation and purification methods, as well as biochemical process control technologies. Due to its advantages of low energy consumption, simple operation, high efficiency, low cost, and compact equipment, membrane separation is increasingly gaining attention in the nucleotide field and playing a growing role in both upstream and downstream production processes.

      Nanofiltration membrane equipment is a separation system with membrane elements featuring "nanoscale pores" as the core separation components. Nanofiltration membranes (NF) fall between ultrafiltration and reverse osmosis, with a molecular weight cutoff of approximately 100Da~1000Da. They are primarily used to remove small organic molecules, dyes, heavy metal ions, etc., achieving desalination, removal of small molecules, and concentration of materials with relatively fast processing speeds. Using nanofiltration membranes for concentrating antibiotics, synthetic drugs, traditional Chinese medicine extracts, and fruit/vegetable juices offers advantages such as ambient temperature operation, non-destructive processing, low cost, and high yield.

      The classification of nanofiltration membrane modules follows the same methods as reverse osmosis, including spiral-wound, hollow fiber, tubular, and plate-and-frame types. However, based on long-term industrial application experience, spiral-wound membrane modules remain dominant in industrial applications. Jiahe Filtration's nanofiltration membrane system can be designed for continuous feed and continuous concentrate discharge, ensuring production continuity, improving equipment utilization efficiency, shortening material residence time in the system, reducing contamination risks, and enhancing product quality and yield.The economic benefits are significant.